Our previous work demonstrated that the Ifnar1−/− day 3 BSI phenotype was at least in part due to the absence of IL-13 as increased susceptibility to BSI at that time post-IAV could be reversed by treating the Ifnar1−/− mice with mrIL-13, leading to a reduction in neutrophils and bacterial burden (9). The gene discussed is IL13; the disease is bathing suit ichthyosis.