IGHE and Increased total eosinophil count: While the continuous exposure to allergen activates T cells and consequently triggers the late phase response, it is the allergen-specific Th2 cells that produce IL-4, IL-5, IL-9, and IL-13, which are responsible for the maintenance of allergen-specific IgE levels and activation of tissue eosinophilia, mucus overproduction, and tissue remodeling (10–13).