N1 neutrophils have potent anti-tumor activity mainly due to their release of pro-inflammatory or immunostimulatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-α, CCL3, CXCL9, CXCL10, which facilitates recruitment and activation of CD8+ T cells (26, 27). This evidence concerns the gene TNF and neoplasm.