Having shown that Afadin downregulation alters the structure of gastric cell–cell junctions and cell morphology, and knowing that Afadin negatively regulates the transcription of Snail to activate EMT in pancreatic cancer cells (Xu et al., 2015), we sought to investigate the involvement of Afadin in the EMT phenotype in the gastric context. The gene discussed is AFDN; the disease is familial pancreatic carcinoma.