Age, sex, season, BMI, systolic blood pressure, education, diastolic blood pressure, smoking, alcohol use, ethnicity, calcium serum levels, estimated glomerular filtration rate, high-density lipoprotein cholesterol, total cholesterol, history of type 2 diabetes, stroke, heart failure, depressive symptoms, myocardial infarction, outdoor activity, APOE ε4. The gene discussed is APOE; the disease is stroke disorder.