Specifically, the average IgE levels (± SEM) in the patients sera with AD (n = 130), AR (n = 120) and BA (n = 145) were 96.19 ± 21.3 ng/ml, 82.17 ± 6.50 ng/ml and 60.58 ± 6.56 ng/ml, respectively (Fig. 3b–d). This evidence concerns the gene IGHE and Alzheimer disease.