IGHE and Alzheimer disease: The average human total IgE (±) SEM in patients’ sera with mild-moderate AD (n = 97), severe AD (n = 33), mild-moderate persistent AR (n = 83), severe persistent AR (n = 37), mild-moderate persistent BA (n = 93) and severe persistent BA (n = 52) was 67.18 ± 10.31, 125.21 ± 40.31, 66.97 ± 8.31, 97.37 ± 5.19, 40.93 ± 7.82 and 80.23 ± 5.25 ng/ml, respectively (Fig. 4c).