GSI stimulation led to the reduction in IL-22 secretion by CD4+ T cells purified from both nontumor site (135.2 ± 24.02 compared with 117.8 ± 16.40 pg/ml, P=0.041, Figure 3D) and tumor site (264.3 ± 79.76 compared with 168.1 ± 68.41 pg/ml, P=0.003, Figure 3D). This evidence concerns the gene CD4 and neoplasm.