ICAM1 and multiple sclerosis: After pooling the different studies together, we observed a reduced risk of multiple sclerosis in the allelic G vs A (Table 2, Passociation = 0.036, OR = 0.91) and dominant AG+GG vs AA (Passociation = 0.042, OR = 0.85) but not in other genetic models (all Passociation > 0.05), thereby suggesting that ICAM1 rs5498 is not a strong susceptibility locus for multiple sclerosis in the whole population.