The abundance of Parabacteroides was increased in colitis‐prone NHE3−/− mice but was decreased in colitis‐prone IL22−/− mice.56, 57 Previous studies have found decreased and increased colonization of Eubacterium in UC and CD patients respectively.58, 59, 60 This study may enrich the relevant knowledge of intestinal microbiota changes in IBD. The gene discussed is SLC9A3; the disease is colitis.