ADPRS and neoplasm: Given the importance of ARH1 as a tumor suppressor (Kato et al., 2011) and its involvement in the defense against bacterial toxins (Kato et al., 2007), as well as the emerging role of ARH3 in the DDR and neurodegenerative disorders (Ghosh et al., 2018, Palazzo et al., 2018), such pharmacological tools would be highly desirable, not only to further elucidate their physiological functions, but also for their potential as therapeutic targets.