More recently in 2017, patients with refractory diffuse B cell lymphoma, primary mediastinal B cell lymphoma, or transformed follicular lymphoma were treated in a multicenter phase II trial with 2 × 106/kg CD19 CD28 CAR T cells following low dose preconditioning regimens with cyclophosphamide (500 mg/m2/day) and fludarabine (30 mg/m2/day) for 3 days. Here, CD19 is linked to B-cell non-Hodgkin lymphoma.