Antiphospholipid syndrome (APS) is an autoimmune disease characterized by a hypercoagulable state associated with vascular thrombosis and/or pregnancy morbidity in the presence of circulating antiphospholipid antibodies (aPL) including immunoglobulin (Ig)G and IgM antibodies to β-2Glycoprotein I (β2GpI) and anticardiolipin antibodies (aCL)1. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.