In clots generated from plasma of both APS and VTE patients the proteins involved in platelet adhesion, activation, and aggregation, like fermitin family homolog 3, multimerin-1, TREM-like transcript-1, integrin alpha-IIb (GPIIb), integrin beta-1 (GPI), integrin beta-3 (GPIII), integrin-linked protein kinase, talin-1, vinculin, filamin A, platelet glycoprotein IX (GPIX), platelet glycoprotein Ib alpha and beta chain (GPIbA, GPIbB), and TSP1 were overrepresented as compared to healthy controls (Fig. 2D, Supplemental Table 1). This evidence concerns the gene GP1BA and autoimmune polyendocrinopathy.