However, in contrast to results for a mouse model of the myelodysplastic syndrome [40], leukaemic transformation was unaffected, as the BCL-2tg/MLL-AF9 and Mcl-1tg/MLL-AF9 AMLs were fully and serially transplantable in non-irradiated mice (Supplementary Table S3). The gene discussed is KMT2A; the disease is myelodysplastic syndrome.