STAT3 and neoplasm: STAT3 is a protein hub for several oncogenic signalling pathways and regulates the expression of key effectors in tumor cell survival (Bcl-xL, Bcl-2, Mcl-1)10, proliferation (Cyclin D1, D2, c-Myc)11,12, angiogenesis (bFGF, VEGF)13,14 and metastasis15.