AR and posterior cortical atrophy: Furthermore, the activity of mTOR and MAPK pathways phosphorylate STAT3 at Serine 727 (S727) which results in direct interaction with the N-terminal domain of AR and enhances AR transcriptional activity23,24, while S727A mutation significantly reduces this interaction; hindering AR transcriptional activity and highlighting the significance of AR/STAT3 co-operation in PCa progression25.