When we further adjusted other clinical characteristics (e.g. diabetes mellitus, cardiovascular disease, duration of dialysis, high-sensitivity C-reactive protein, serum albumin, serum sodium, serum creatinine, intact parathyroid hormone, measured glomerular filtration rate), the association between coexisting frailty and cognitive impairment and mortality was not significant (HR 0.24; 95% CI 0.73~3.53; P = 0.24). This evidence concerns the gene CRP and diabetes mellitus.