We found that mPDCA-1-mediated depletion of pDCs in Aim2−/−, Nlrp3−/−, Casp1−/−, and Il1r1−/− mice markedly decreased serum levels of IFN-α/β at day 1 after YM infection, compared with those treated with control antibody (Fig. 5b–e). This evidence concerns the gene CASP1 and infection.