To address this issue, we isolated pDCs from YM-infected WT and gene deficient (Aim2−/−, Nlrp3−/−, Casp1−/−, Il1r1−/−, and Mavs−/−) mice at 18 h post YM infection and assessed mRNA expression levels of SOCS1, IFN-α and IFN-β. The gene discussed is CASP1; the disease is infection.