Our findings suggest that Plasmodium nucleic acid is preferentially taken up by pDCs at first 24 h post YM infection and induce large amount of IFN-α/β production by activating MyD88-IRF7 dependent type I IFN signaling through blocking IL-1β-mediated MyD88-TRAF3-IRF3 signaling and SOCS1 expression in inflammasome-deficient mice. Here, MYD88 is linked to infection.