We first isolated pDCs, cDCs and macrophages from WT mice at different times post YM infection, and found that malaria 18S rRNA was only detected in pDCs, but not in cDCs and macrophages at 18 h post YM infection (Fig. 5a), suggesting that pDC is mainly responsible for uptake of YM parasite nucleic acid during infection. Here, PDC is linked to infection.