Moreover, tumor size and number were significantly decreased in Atg7/Yap het DKO mice and Atg7/Yap DKO mice compared to Atg7 KO at 12 months after tamoxifen administration (Fig. 3b, e, f, Supplementary Fig. 6D, E) thereby identifying Yap as a driver of liver growth and hepatocarcinogenesis when autophagy is impaired. Here, YAP1 is linked to neoplasm.