FZD5 and hepatocellular carcinoma: CircRNA cSMARCA5 and circMTO1, associated with tumor aggressive characteristics, suppress the growth and metastasis of HCC by sponging miR-17-3p, miR-181b-5p and miR-9 [17, 18], whereas circ_0067934 favors the growth and metastasis of HCC by regulating miR-1324/FZD5/Wnt/β-catenin signaling [19].