HOXD3 and posterior cortical atrophy: To investigate whether combinations of biomarkers were more informative compared to individual markers for detection of any PCa and/or aggressive PCa, we applied least absolute shrinkage and selection operator (LASSO) and constructed an optimal two-gene (HOXD3 and GSTP1) classifier model (ProCUrE) in the training cohort comparing between benign vs CAPRA-HR patients.