The IQR OR of ProCUrE in the validation cohort (OR = 1.58, 95% CI = 1.28–1.96) were of similar size to PSA (OR = 1.98, 95% CI = 1.46–2.68), and age (OR = 1.66, 95% CI = 1.13–2.45) for CS-PCa (Table 4A). This evidence concerns the gene KLK3 and posterior cortical atrophy.