Methylation frequencies (patients with percent methylated of reference (PMR) > 0) ranged from 39.5% (161/408 patients) for GSTP1 to 92.6% (378/408 patients) for HOXD3. PMR distribution for individual markers among benign and PCa patients is shown in Fig. 1. This evidence concerns the gene GSTP1 and posterior cortical atrophy.