IP-10 is secreted by several cell types in response to IFN-γ, and experimental studies have shown that IP-10 is highly induced in the CNS (e.g., West Nile infections [46], HIV encephalitis [47], HSV encephalitis [48], enteroviral encephalitis [3, 49], Japanese encephalitis [50], and tick-borne encephalitis [TBE] [51]). Here, IFNG is linked to tick-borne encephalitis.