While some studies reported that increased cIMT was mediated in part by obesity [19], insulin sensitivity [20], type 2 diabetes [21], DBP [22], SBP, inflammatory markers [23], epicardial adipose tissue thickness [24], WC [22, 25], others found no associations between cIMT and insulin resistance [14, 26], prediabetes state [27], polycystic ovary syndrome [28], and inflammatory chemokines [29]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.