(Shi et al. 2018) have demonstrated that Saikosaponin-d, a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump (SERCA) inhibitor, inhibits proliferation by up-regulating autophagy via the CaMKKβ/AMPK/mTOR pathway in ADPKD (autosomal dominant polycystic kidney disease) cells. Here, CAMKK2 is linked to autosomal dominant polycystic kidney disease.