Moreover, the TGFß-induced EMT can be initiated by suppressing the SMAD inhibitors, such as SMAD7. Thereby, miR-4775, miR-1269 and miR-21 promote CRC metastasis in a SMAD7/TGFβ signaling-dependent manner [96,97,98]. Here, TGFB1 is linked to colorectal carcinoma.