In these cancers, matriptase has a significant correlation with increased invasive and metastatic activity through its potential to activate several growth factors, including pro-HGF, protease-activated receptor 2 (PAR-2), pro-platelet-derived growth factor D (PDGF-D) and pro-macrophage stimulating protein (MSP)-1 [8]. Here, F2RL1 is linked to cancer.