This miRNA was also found hyperexpressed in adipocytes from HFD mice and its function has been associated to adipogenesis in mouse and human context as well [92,93]; we may therefore speculate that increased expression of miR-222 may dampen insulin signaling in adipocytes by targeting IRS1 as well as others downstream effectors, thus contributing to insulin resistance also in adipocytes. The gene discussed is INS; the disease is Insulin resistance.