IGF1 and Insulin resistance: Moreover, miR-214 is able to regulate IGF-1-stimulated Akt kinase activity in renal carcinoma cells [142]; of note, as previously reported, miR-214 has been tightly associated with insulin resistance in endothelial cells [133] and in muscle cell lines alongside with miR-135 and miR-202, thus underlining the potential role of miR-214 to contribute to insulin resistance through multiple networks regulation as previously reported for let-7 [133,143].