Finally, IRS1 was also demonstrated to be a target gene of miR-126a in mouse endothelial cells, involved in the control of cell viability and proliferation; specifically, miR-126a was found downregulated in retinal endothelial cells from a mouse model of diabetic retinopathy and contributed, through IRS1 modulation, to dysfunctional angiogenesis [101]. Here, IRS1 is linked to diabetic retinopathy.