PTEN and Insulin resistance: In hepatocytes, glycogen synthesis mediated by insulin signaling has been widely associated with miRNA-PTEN regulatory networks; indeed, it has been demonstrated that miR-152 [106], miR-19 [107], miR-20-5p [108], and miR-499-5p [109] directly target PTEN phosphatase and were reported to be downregulated in liver from T2D mouse models (e.g., db/db mice), paralleled by PTEN hyperexpression and signs of hepatic insulin resistance.