In addition, immunolocalization of CD8+ cells in omental tumor tissue samples harvested from the ISG15 treated and the control mice demonstrated a significant increase in intraepithelial CD8+ lymphocyte density in ISG15 treated mice than in control mice (Figure 7B) suggesting that ISG15 treatment facilitated T cell infiltration into the tumor tissue and promoted cancer cell eradication. Here, CD8A is linked to cancer.