CTHRC1 and non-small cell lung carcinoma: Consistent with CTHRC1 inducing NSCLC cell proliferation in our hand (Figure S5C) and a previous publication [27], H1993 cell viability, in vitro, was indeed decreased when the cells were incubated with conditioned medium of cultured osteoclasts; the medium of osteoclasts from Tgfbr2LysMCre KO mice had a lesser amount of CTHRC1 than that from Tgfbr2floxE2/floxE2 mice (Figure S5D).