IGF1 and hyperinsulinemic hypoglycemia, familial, 4: IGF-1 deficiency is associated with decreased lifespan and increased incidence of fatal atherosclerotic CV events [105,106], and IGF-1 supplementation with recombinant human IGF-1 analogs (mecasermin and mecasermin rinfabate) appears to efficiently revert CV remodeling and to improve lipid profile [107].