More recently, Kotake et al. [73] in discussing the plasticity of Th17 cells showed that in peripheral blood of early-onset RA patients, the ratio of CD161+ Th1 was elevated, which correlated with IFN-γ from (INF-γ)+Th17 cells and was inversely related to anti-CCP antibodies. Here, IFNG is linked to rheumatoid arthritis.