However, pretreatment of FLS with IFN-γ blunted rTRAIL-induced apoptosis suggesting that pro-inflammatory cytokines such as IFN-γ which activate JAK-STAT signaling [38] may be involved in suppressing rTRAIL-mediated apoptosis in T-cells and RA-FLS. This evidence concerns the gene IFNG and rheumatoid arthritis.