MUC16 and cancer: Due to the increased necessity of early diagnosis of cancer, several immunological assays have been reported for the detection of the cancer biomarker CA125 using electrochemical biosensors, nanomaterial-based colorimetric immunoassays, arrayed microsensor chips, bead-based enzyme-linked immunosorbent assay (ELISA), and a fluorescent immunoassay employing the ALYGNSA antibody orientation system [44,45,46,47,48,49,50].