In multivariable Cox analysis after adjustment for age, body muscle mass, BMI, SBP, smoking and alcohol status, history of HTN, DM and CVDs, hemoglobin, fasting plasma glucose, albumin, total cholesterol, and CRP, the increased risk for proteinuria development was observed in highest quartile (HR, 4.87; 95% CI, 3.41–6.96 in female subjects; HR, 13.06; 95% CI, 7.86–21.69 in male subjects; Table 3). The gene discussed is ALB; the disease is hypertensive disorder.