In ROC curve analysis, sCr levels improved the accuracy of predicting the development of eGFR <60 mL/min/1.73 m2 when added to the traditional risk factors for CKD, including age, SBP, BMI, history of HTN, DM, CVDs, hemoglobin, fasting plasma glucose, albumin, and total cholesterol in both female and male subjects (AUC 0.80 vs. 0.83; p < 0.001 in female subjects; AUC 0.78 vs. 0.85; p < 0.001 in male subjects; Figure 4A,B). The gene discussed is ALB; the disease is diabetes mellitus.