After adjustment for age, body muscle mass, BMI, SBP, smoking and alcohol status, history of HTN, DM, CVDs, hemoglobin, fasting plasma glucose, albumin, total cholesterol, CRP, and proteinuria, an increased risk for the development of eGFR <60 mL/min/1.73 m2 was observed in those in the higher quartiles compared to those in the lowest quartile in both female and male subjects (Table 2). This evidence concerns the gene CRP and hypertensive disorder.