Moreover, age, muscle mass, body mass index, systolic blood pressure, history of HTN, DM, and CVDs, fasting plasma glucose, and presence of proteinuria were significantly associated with increased risk of the development of eGFR <60 mL/min/1.73 m2, whereas alcohol status, hemoglobin, and serum albumin were related to decreased risk in male subjects. This evidence concerns the gene ALB and hypertensive disorder.