The hepcidin-stimulating effects of vorinostat in Huh7 hepatoma cells were also validated in another study [75], and are consistent with earlier data showing that the histone deacetylase inhibitor trichostatin A induces hepcidin by inhibiting the binding of C/EBPα and STAT3 in the HAMP promoter [76]. This evidence concerns the gene HAMP and hepatocellular carcinoma.