For example, in an in vitro AD model, the expression of antisense ubiquitin carboxyl-terminal hydrolase L1 (antisense Uchl1) increased, and this in turn led to an increase in the synthesis of the UCHL1 protein, a deubiquitinating enzyme involved in AD pathogenesis, at the posttranscriptional level [70]. Here, UCHL1 is linked to Alzheimer disease.