For example, LTβR−/− mice are sensitive to bacterial infection due to the absence of lymphoid organs in these mice, and LTβR signaling in intestinal epithelial cells is required for the recruitment of neutrophils to the site of infection during early infection via the production of CXCL1 and CXCL2 [6,27]. The gene discussed is CXCL2; the disease is bacterial infectious disease.