Other cohesinopathies include Cornelia de Lange syndrome (CdLS), caused by mutations in genes encoding cohesin structural components (SMC1A, SMC3 and RAD21) and regulators (NIPBL and HDAC8) and Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, linked to mutations in the SGOL1 gene encoding Shugoshin [88,89,90]. This evidence concerns the gene HDAC8 and Cornelia de Lange syndrome.