Genes up-regulated in the tumor tissues were GPX1, GPX2, SELENOH, TXNRD3, and SOD2, while those down-regulated included GPX3, SELENOP, SELENOS, SEPHS2, SELENBP1, SELENON, and SELENOK. In adenomas GPX2, SELENOH, and TXNRD3 also exhibited a higher expression in the disease tissue, while GPX3, SELENOP, SELENOS, and SEPHS2 showed a lower expression for the Czech cancers. This evidence concerns the gene GPX3 and cancer.