Overall, the apparent expression pattern we assessed in the colorectal tumor tissue is that the genes related to Se homeostasis (SELENOP, SEPHS2, SELENBP1) and ER stress (SELENOK, SELENOS) are down-regulated, while the antioxidant enzymes might exhibit a higher (GPX1, GPX2, SELENOH, TXNRD3, SOD2) or lower (GPX3, SELENON) expression [3,6,8]. The gene discussed is SELENOK; the disease is colorectal neoplasm.