Transcriptomics animal studies highlight Gpx1, Selenof, Selenoh, and Selenow as being sensitive to Se supply and human Single Nucleotide Polymorphism (SNP) studies suggest SELENOP, SELENOS, GPX4, SELENOF, SELENON, SELENOH, and TXNRD1-3 are key selenoproteins for colonic function and colorectal carcinogenesis [8,16,27,28]. This evidence concerns the gene SELENOF and medical procedure.