To examine the pattern of selenoprotein gene expression in CRA and CRC disease tissue and the surrounding non-neoplastic mucosa, the mRNA transcript expression level of seventeen Se pathway genes (including fifteen selenoproteins, the related SELENBP1 Se biosynthesis gene, and the interacting SOD2 antioxidant gene [16]) was evaluated for one hundred and sixty-seven Irish and Czech individuals (forty CRA and a hundred and twenty-seven CRC patients) by quantitative real-time PCR (qPCR). This evidence concerns the gene SOD2 and colorectal carcinoma.