Importantly, USP10 was colocalized with α-synuclein of Lewy bodies in PD, and colocalization of USP10 and α-synuclein in Lewy bodies resembled those in aggresomes of cultured cells, suggesting that USP10 promotes Lewy body formation by an aggresome-related mechanism and inhibits neurotoxicities. The gene discussed is USP10; the disease is Parkinson disease.