Although evidence exists that overexpression of DNMTs, especially DNMT3B, correlates with the epigenetic inactivation of tumor suppressor genes and tumor formation, primary tumors accrue substantial CGI methylation while the global average decays, and without temporal analysis, it cannot be ascertained whether global and local misregulation co-occur or if they represent distinct regulatory modes that arise independently (Baylin and Jones, 2011; Ben Gacem et al., 2012; Butcher and Rodenhiser, 2007; Girault et al., 2003; Portela and Esteller, 2010; Roll et al., 2008; Steine et al., 2011). This evidence concerns the gene DNMT3B and neoplasm.