LEF1 and melanoma: Numerous studies investigated TCF1 and LEF1 transcription factors in various tumour types including colon, kidney, breast, adenocarcinoma, melanoma, several different types of leukaemia and lymphoma60, 61, 62 and concluded that their expression is important in maintaining the physiological functions of cells, while their overexpression causes invasion of tumour cells60 and promotes epithelial‐to‐mesenchymal transition.63