All things considered, it is clear that LOH and MSI contribute to the genomic profile of astrocytoma.46, 47, 48, 49The levels of DVL1, DVL2 and DVL3 protein expressions were studied as the functional consequences of each Dishevelled homologue on astrocytoma tumour formation are still not fully clarified, and the data from the literature are contradictory. The gene discussed is DVL1; the disease is astrocytoma (excluding glioblastoma).