Most studies report on gene amplifications and high expression of DVL proteins in general,17, 50 but others describe large deletions of these genes as well.51, 52 Although our results generally showed higher DVL1 expression levels when compared to the control tissue, when dividing the sample to malignancy grade groups it became obvious that the expression levels of DVL1 differed significantly across tumour grades (P < 0.001). This evidence concerns the gene DVL1 and neoplasm.