DVL3 and pilocytic astrocytoma: Comparing the IRS values for DVL2 and DVL3, statistically significant negative correlation was established only for pilocytic astrocytomas (r = −0.699, t = −3.388, P = 0.005), while anaplastic astrocytomas showed a trend of negative correlation for the two proteins (r = −0.488, t = 0.236, P = 0.077) (Figure 5C).