Increased endothelial permeability and angiogenesis were also prevented, and similar functional alterations were seen in the human retina from enucleated eyes obtained from patients with diabetes.48 In another study of the same research group, HG‐induced EndMT caused a reduction in miR‐200b (>30%) and the up‐regulation of VEGF and p300 in cultured hRECs. Here, EP300 is linked to diabetes mellitus.