IGF2 and neoplasm: For instance, overexpression of let‐7a suppressed PTC cell migration and tumour growth by targeting AKT2.42 Exogenous IGF‐2 expression, a potent stimulus facilitated cancer progression, could reversed NEAT1‐knockdown‐induced growth inhibition, might be a direct target of let‐7a.43 Thus, overexpression of let‐7a suppressed cell migration and angiogenesis, which also supported our study that shown in Figure 2.