Based on above‐mentioned findings, we evaluated the serum exosomal expressions of 11 lncRNAs (PCAT‐1, SPRY4‐IT1, MALAT1, UCA1, TUG1, UBC1, GHET1, H19, SNHG16, MEG3 and BC039493) which have been previously reported to be differently expressed in BC tissues. The gene discussed is SPRY4; the disease is breast cancer.