Also, the type of tau accumulations in AD versus FTLD differs, with both 3 repeat and 4 repeat tau isoforms incorporated into the neuritic pathology in AD, while only 4 repeat tau isoforms are incorporated into the neuritic pathology of the FTLD-tau cases analyzed in this study (Goedert et al. 1989; Yoshida 2006; Dickson et al. 2011). This evidence concerns the gene MAPT and Alzheimer disease.