Neuropathologically, TDP43 and tau protein aggregates are present in the majority of FTLD cases (IR and Manuela 2016) while extracellular β-amyloid plaques produced from amyloid precursor protein (APP) and intracellular hyperphosphorylated tau tangles are the hallmarks of AD (Bloom 2014). The gene discussed is TARDBP; the disease is Alzheimer disease.