No correlation was found between EV-TF activity and aPTT-LA (rho = 0.034), Rosner index (rho = − 0.056), anti-β2GPI IgG (rho = 0.05), anti-β2GPI IgM (rho = − 0.08), aCL IgG (rho = 0.12), and aCL IgM (rho = − 0.11) in LA-positive patients with a history of thrombosis. This evidence concerns the gene CD40LG and Venous thrombosis.