MICA and hepatocellular carcinoma: For instance, sorafenib, a kinase inhibitor used to treat HCC, can inhibit the shedding of MICA from HCC cells [28] and combinatorial immunotherapy of sorafenib with blockade of programmed death-ligand 1 generates potent immune responses that can result in NK cell-mediated eradication or reduction of tumor growth in tumor-bearing mice [29].