Recently, there has been growing interest in understanding the role of sortilin in vascular disease after the initial GWAS studies found the 1p13 locus harboring the SORT 1 gene encoding the protein sortilin to be associated with LDL, myocardial infarction, abdominal aortic aneurysms and CAC (82–85). The gene discussed is SORT1; the disease is abdominal aortic aneurysm.