S100A12 and atherosclerosis: However, when S100A12 transgenic mice were crossed with atherosclerosis prone ApoE null mouse, we noted an increase in atherosclerotic plaque size characterized by a very large increase in calcified intimal plaque and in medial calcification in S100A12/ApoE null compared to their wild type/ApoE null littermate mice (Figure 2C) (44).