Further, S100A12 mRNA in peripheral blood cells was one of the most significantly reduced genes (among 142 other genes that were differentially expressed from baseline) in 63 participants with coronary artery disease or ≥2 CAD risk factors after 52 weeks of a rigorous cardiovascular disease risk reduction program with comprehensive life style changes (37), demonstrating that S100A12 expression in leucocytes is a modifiable risk factor. The gene discussed is S100A12; the disease is cardiovascular disorder.