After further adjustments for other inflammatory markers (hs-CRP, CD40, IL-8, IL-18, and other inflammatory markers) and for traditional risk factors (diabetes, hypertension, chronic kidney disease, smoking, body mass index, hyperlipidemia, white blood cell count), S100A12 remained associated with acute myocardial infarction and cardiovascular mortality, suggesting that S100A12 represents a distinct inflammatory pathway related to athero-thrombosis. Here, S100A12 is linked to acute myocardial infarction.