Dr. Aimee Payne (University of Pennsylvania, Philadelphia, PA, USA) discussed strategies to move CAART technology forward to clinical trials in both mucosal PV, caused by antibodies to Dsg3, and in mucocutaneous PV, characterized by autoantibodies to Dsg3 and the homologous protein Dsg1. This evidence concerns the gene DSG3 and acquired polycythemia vera.