Adapted from a groundbreaking gene-engineered chimeric antigen receptor (CAR) T cell therapy that has led to long-lasting remissions of previously refractory B cell leukemia and lymphoma, Dsg3 chimeric autoantibody receptor T cell (DSG3-CAART) therapy has been shown to induce histologic and serologic remission of experimental pemphigus without detectable off-target toxicity in preclinical mouse models (9). This evidence concerns the gene DSG3 and pemphigus.