Regarding the tumor size and number of nodules, comparison between HCC patients with one tumor nodule (T1) and those with two or more tumor nodules (T2/Tm) revealed that the first group was statistically significantly lower than the second group for AFP (Z=3.1, p<0.01) and lamin B1 (Z=4.5, p<0.001) levels. This evidence concerns the gene LMNB1 and hepatocellular carcinoma.