Plasma levels of lamin B1 mRNA (2-ΔΔCq) was significantly higher in HCC patients than in chronic liver disease (CLD) patients and healthy controls with median (Q1–Q3) 3.9 (2–13.3), 0.9 (0.8–1.1) and 1 (0.9–1.2), respectively. This evidence concerns the gene LMNB1 and congenital secretory chloride diarrhea 1.