To understand how mutant Kras with p53 inactivation promotes PCA invasion and metastasis, we conducted systemic analyses of differential gene expression profiles to identify several upregulated cancer-associated genes (CD24a, EPCAM, Tmprss11e, Fermt1, E-cadherin, Claudins and promin1 (CD133)) as potential effectors of mutant KrasG12D compared to normal murine and BRAFV660E-driven PCA cells. Here, TP53 is linked to cancer.