Since mutant K-Ras may enhance autocrine EGFR ligand expression to trigger multiple signaling pathway in many cancers, we also observed that PKP mice had significantly higher EGFR, p-ERK (p-p44/42), and p-Akt than PBP mice (Fig. 3e, Supplementary Table S2) [28]. The gene discussed is EGFR; the disease is cancer.