Ganetespib-responsive LuCaPs spanned a spectrum of CRPC phenotypes including: adenocarcinomas with wild-type AR (LuCaPs: 23.1, 73, 77, 96, 136, 147), adenocarcinomas with altered AR (LuCaPs: 86.2, 92, 141, 167), neuroendocrine disease (LuCaP 145.1, 145.2), and two experimentally-derived models (86.2CR, 96CR) selected as castrate-resistant in mouse hosts. This evidence concerns the gene AR and adenocarcinoma.